Wong, M.Y.; DiChiara, A.S.; Doan, N.-D.; Papa, L.J., III; Cheah, J.H.; Soule, C.K.; Watson, N.; Hulleman, J.D.; Shoulders, M.D. "High-Throughput Assay for Collagen Secretion Suggests an Unanticipated Role for Hsp90 in Collagen Production" 2018in revision. 

Cole, K.S.; Grandjean, J.M.D.; Chen, K.; Witt, C.H.; O'Day, J.; Shoulders, M.D.; Wiseman, R.L.; Weerapana, E. "Characterization of an A-Site Selective Protein Disulfide Isomerase A1 Inhibitor" 2018, in review.

Richardson, C.E.R.; Cunden, L.S.; Butty, V.L.; Nolan, E.M.; Lippard, S.J.; Shoulders, M.D. "A Method for Selective Depletion of Zn(II) Ions from Complex Biological Media and Evaluation of Cellular Consequences of Zn(II) Deficiency" Journal of the American Chemical Society 2018, 140, in press.

Wong, M.Y.; DiChiara, A.S.; Suen, P.H.; Chen, K.; Doan, N.-D.; Shoulders, M.D. "Adapting Secretory Proteostasis and Function Through the Unfolded Protein ResponseCurrent Topics in Microbiology and Immunology 2017400, in press.

Phillips, A.M.; Gonzalez, L.O.; Nekongo, E.E.; Ponomarenko, A.I.; McHugh, S.M.; Butty, V.; Levine, S.S.; Lin, Y.-S.; Mirny, L.A.; Shoulders, M.D. "Host Proteostasis Modulates Influenza EvolutioneLife 20176, e28652.

Maji, B.#; Moore, C.L.#; Zetsche, B.; Volz, S.E.; Zhang, F.; Shoulders, M.D.*; Choudhary, A.* "Multidimensional Chemical Control of CRISPR-Cas9" Nature Chemical Biology 201713, 911. #Co-First Authors; *Co-Corresponding Authors.

DiChiara, A.S.; Taylor, R.J.; Wong, M.Y.; Doan, N.-D.; Del Rosario, A.; Shoulders, M.D. "Mapping and Exploring the Collagen-I Proteostasis Network" ACS Chemical Biology 201611, 1408–1421.

Moore, C.L.; Dewal, M.B.; Nekongo, E.E.; Santiago, S.; Lu, N.B.; Levine, S.S.; Shoulders, M.D. "Transportable, Chemical Genetic Methodology for the Small Molecule-Mediated Inhibition of Heat Shock Factor 1ACS Chemical Biology 2016, 11200–210.

Phillips, A.M.; Shoulders, M.D. "The Path of Least Resistance: Mechanisms to Reduce Influenza's Sensitivity to OseltamivirJournal of Molecular Biology 2016, 428533–537.

Dewal, M.B.; DiChiara, A.S.; Antonopoulos, A.; Taylor, R.J.; Harmon, C.J.; Haslam, S.M.; Dell, A.; Shoulders, M.D. "XBP1s Links the Unfolded Protein Response to the Molecular Architecture of Mature N-Glycans" Cell Chemical Biology 2015, 22, 1301–1312.

Genereux, J.C.; Qu, S.; Zhou, M.; Ryno, L.M.; Wang, S.; Shoulders, M.D.; Kaufman, R.J.; Lasmézasm C.I.; Kelly, J.W.; Wiseman, R.L. "Unfolded Protein Response-Induced ERdj3 Secretion Links Endoplasmic Reticulum Stress to Extracellular ProteostasisEMBO Journal 2015, 34, 419.

Choudhary, A.1; Kamer, K.J.1; Shoulders, M.D.1; Raines, R.T. "4-Ketoproline: An Electrophilic Proline Analog for BioconjugationBiopolymers: Peptide Science 2015, 104, 110115. 1Equal Contribution.

Chen, J.J.1; Genereux, J.C.1; Hulleman, J.D.; Shoulders, M.D.; Wiseman, R.L. “ATF6 Activation Reduces the Secretion and Extracellular Aggregation of Destabilized Variants of an Amyloidogenic ProteinCell Chemical Biology 2014, 21156415741Equal Contribution.

Ryno, L.M.; Genereux, J.C.; Naito, T.; Morimoto, R.I.; Powers, E.T.; Shoulders, M.D.; Wiseman, R.L. "Characterizing the Altered Cellular Proteome Induced by the Stress-Independent Activation of Heat Shock Factor I" ACS Chemical Biology 2014, 9, 12731283.

Shoulders, M.D.1; Ryno, L.M.1; Kelly, J.W.; Wiseman, R.L. “Broadly Applicable Methodology for the Dosable, Rapid, and Small Molecule-Mediated Regulation of Transcription Factors in Human Cells” Journal of the American Chemical Society 2013135, 8129–8132. 1Equal Contribution.

Shoulders, M.D.; Ryno, L.M.; Genereux, J.C.; Moresco, J.J.; Tu, P.G.; Wu, C.; Yates, J.R. III; Su, A.I.; Kelly, J.W.; Wiseman, R.L. “Stress-Independent Activation of XBP1s and/or ATF6 Reveals Three Functionally Diverse ER Proteostasis Environments” Cell Reports 20133, 1279–1292.

Krow, G.R.1; Shoulders, M.D.; Edupuganti, R.; Gandla, D.; Yu, F.; Sonnet, P.E.; Sender, M.; Choudhary, A.; DeBrosse, C.; Ross, C.W.,III; Carroll, P.; Raines, R.T.1 “Synthesis of 5-Fluoro- and 5-Hydroxymethanoprolines via Lithiation of N-BOC-Methanopyrrolidines. Constrained Cg-Exo and Cg-Endo Flp and Hyp Conformer Mimics” Journal of Organic Chemistry 201277, 5331–5344. 1Co-Senior Author.

Shoulders, M.D.; Raines, R.T. “Interstrand Dipole-Dipole Interactions Can Stabilize the Collagen Triple Helix” Journal of Biological Chemistry 2011286, 22905–22912.

Krow, G.R.1; Edupuganti, R.; Gandla, D.; Yu, F.; Sender, M.; Sonnet, P.E.; Zdilla, M.J.; DeBrosse, C.; Cannon, K.C.; Ross, C.W., III; Choudhary, A.; Shoulders, M.D.; Raines, R.T.1 “Synthesis of Conformationally Constrained 5-Fluoro- and 5-Hydroxymethanopyrrolidines. Ring Puckered Mimics of Gauche and Anti-3-Fluoro- and 3-Hydroxypyrrolidines” Journal of Organic Chemistry 201176, 3626–3634. 1Co-Senior Author.

Shoulders, M.D.; Kotch F.W.; Choudhary, A.; Guzei, I.A.; Raines, R.T. “The Aberrance of the 4S Diastereomer of 4-Hydroxyproline” Journal of the American Chemical Society, 2010132, 10857–10865.

Shoulders, M.D.; Satyshur, K.A.; Forest, K.T.; Raines, R.T. “Stereoelectronic and Steric Effects in Side Chains Preorganize a Protein Main Chain” Proceedings of the National Academy of Sciences, USA 2010107, 559–564.

Krow, G.R.; Liu, N.; Sender, M.; Lin, G.; Centafont, R.; Sonnet, P.E.; DeBrosse, C.; Ross, C.W., III; Carroll, P.J.; Shoulders, M.D.; Raines, R.T. “Oligomers of a 5-Carboxymethanopyrrolidine b-Amino Acid—A Search for Order” Organic Letters 201012, 5438–5441.

Shoulders, M.D.; Kamer, K.J.; Raines, R.T. “Origin of the Stability Conferred upon Collagen by Fluorination” Bioorganic and Medicinal Chemistry Letters 200919, 3859–3862.

Shoulders, M.D.; Raines, R.T. “Collagen Structure and Stability” Annual Review of Biochemistry 2009,78, 929–958.

Shoulders, M.D.; Raines, R.T. “Modulating Collagen Triple-Helix Stability with 4-Chloro, 4-Fluoro, and 4-Methylprolines” Advances in Experimental Medicine and Biology 2009611, 251–252.

Shoulders, M.D.; Guzei, I.A.; Raines, R.T. “4-Chloroprolines: Synthesis, Conformational Analysis, and Effect on the Collagen Triple Helix” Biopolymers 200889, 443–454.

Shoulders, M.D.; Hodges, J.A.; Raines, R.T. “Reciprocity of Steric and Stereoelectronic Effects in the Collagen Triple Helix” Journal of the American Chemical Society 2006128, 8112–8113.