Sebastian, R.M.; Shoulders, M.D. "Chemical Biology Framework to Illuminate Proteostasis" Annual Review of Biochemistry 2019, in press.

Wong, M.Y.; Shoulders, M.D. "Targeting Defective Proteostasis in the Collagenopathies" Current Opinion in Chemical Biology 2019, 50, 80–88.

Liebelt, F.#; Sebastian, R.M.#; Moore, C.L.; Mulder, M.P.C.; Ovaa, H.; Shoulders, M.D.*; Vertegaal, A.C.O.* "SUMOylation and the HSF1-Regulated Chaperone Network Converge to Promote Proteostasis in Response to Heat ShockCell Reports 201926, 236–249. #Co-First Authors; *Co-Corresponding Authors.

Doan, N.-D.; DiChiara, A.S.; Del Rosario, A.M.; Schiavoni, R.P.; Shoulders, M.D. "Mass Spectrometry-Based Proteomics to Define Intracellular Collagen InteractomesMethods in Molecular Biology 20191944, 95–114.

Papa, L.J., III; Shoulders, M.D. "Genetic Engineering by DNA RecombineeringCurrent Protocols in Chemical Biology 201911, e70.

Wong, M.Y.#; Chen, K.#; Antonopoulos, A.#; Kasper, B.T.#; Dewal, M.B.; Taylor, R.J.; Whittaker, C.A.; Hein, P.P.; Dell, A.; Genereux, J.C.; Haslam, S.M.; Mahal, L.K.; Shoulders, M.D. "XBP1s Activation Can Globally Remodel N-Glycan Structure Distribution PatternsProceedings of the National Academy of Sciences, USA 2018115, E10089–E10098#Co-First Authors.

DiChiara, A.S.; Li, R.C.; Suen, P.H.; Hosseini, A.S.; Taylor, R.J.; Weickhardt, A.F.; Malhotra, D.; McCaslin, D.R.; Shoulders, M.D. "A Cysteine-Based Molecular Code Informs Collagen C-Propeptide AssemblyNature Communications 20189, e4206.

Phillips, A.M.#; Ponomarenko, A.I.#; Chen, K.; Ashenberg, O.; Miao, J.; McHugh, S.M.; Butty, V.L.; Whittaker, C.A.; Moore, C.L.; Bloom, J.D.; Lin, Y.-S.; Shoulders, M.D. "Destabilized Adaptive Influenza Variants Critical for Innate Immune System Escape are Potentiated by Host ChaperonesPLoS Biology 201816, e3000008. #Co-First Authors.

Phillips, A.M.; Doud, M.B.; Gonzalez, L.O.; Butty, V.L.; Lin, Y.-S.; Bloom, J.D.; Shoulders, M.D. "Enhanced ER Proteostasis and Temperature Differentially Impact the Mutational Tolerance of Influenza HemagglutinineLife 20187, e38795.

Berman, C.M.#; Papa, L.J., III#; Hendel, S.J.#; Moore, C.L.; Suen, P.H.; Weickhardt, A.F.; Doan, N.-D.; Kumar, C.S.; Uil, T.G.; Butty, V.L.; Hoeben, R.C.; Shoulders, M.D. "An Adaptable Platform for Directed Evolution in Human CellsJournal of the American Chemical Society 2018140, 18093–18103. #Co-First Authors.

Moore, C.L.#; Papa, L.J., III#; Shoulders, M.D. "A Processive Protein Chimera Introduces Mutations across Defined DNA Regions In VivoJournal of the American Chemical Society 2018140, 11560–11564. #Co-First Authors.

Richardson, C.E.R.; Cunden, L.S.; Butty, V.L.; Nolan, E.M.; Lippard, S.J.; Shoulders, M.D. "A Method for Selective Depletion of Zn(II) Ions from Complex Biological Media and Evaluation of Cellular Consequences of Zn(II) DeficiencyJournal of the American Chemical Society 2018140, 2413–2416.

Richardson, C.E.R.; Nolan, E.M.; Shoulders, M.D.*; Lippard, S.J.* "A Sensitive, Non-Radioactive Assay for Zn(II) Uptake into Metazoan CellsBiochemistry 201857, 6807–6815. *Co-Corresponding Authors.

Wong, M.Y.; Doan, N.-D.; DiChiara, A.S.; Papa, L.J., III; Cheah, J.H.; Soule, C.K.; Watson, N.; Hulleman, J.D.; Shoulders, M.D. "High-Throughput Assay for Collagen Secretion Suggests an Unanticipated Role for Hsp90 in Collagen Production" Biochemistry 201857, 2814–2827

Cole, K.S.; Grandjean, J.M.D.; Chen, K.; Witt, C.H.; O'Day, J.; Shoulders, M.D.; Wiseman, R.L.; Weerapana, E. "Characterization of an A-Site Selective Protein Disulfide Isomerase A1 Inhibitor" Biochemistry 2018, 57, 2035–2043.

Wong, M.Y.; DiChiara, A.S.; Suen, P.H.; Chen, K.; Doan, N.-D.; Shoulders, M.D. "Adapting Secretory Proteostasis and Function Through the Unfolded Protein ResponseCurrent Topics in Microbiology and Immunology 2018414 125.

Phillips, A.M.; Gonzalez, L.O.; Nekongo, E.E.; Ponomarenko, A.I.; McHugh, S.M.; Butty, V.; Levine, S.S.; Lin, Y.-S.; Mirny, L.A.; Shoulders, M.D. "Host Proteostasis Modulates Influenza EvolutioneLife 20176, e28652.

Maji, B.#; Moore, C.L.#; Zetsche, B.; Volz, S.E.; Zhang, F.; Shoulders, M.D.*; Choudhary, A.* "Multidimensional Chemical Control of CRISPR-Cas9" Nature Chemical Biology 201713, 911. #Co-First Authors; *Co-Corresponding Authors.

DiChiara, A.S.; Taylor, R.J.; Wong, M.Y.; Doan, N.-D.; Del Rosario, A.M.; Shoulders, M.D. "Mapping and Exploring the Collagen-I Proteostasis Network" ACS Chemical Biology 201611, 1408–1421.

Moore, C.L.; Dewal, M.B.; Nekongo, E.E.; Santiago, S.; Lu, N.B.; Levine, S.S.; Shoulders, M.D. "Transportable, Chemical Genetic Methodology for the Small Molecule-Mediated Inhibition of Heat Shock Factor 1ACS Chemical Biology 2016, 11200–210.

Phillips, A.M.; Shoulders, M.D. "The Path of Least Resistance: Mechanisms to Reduce Influenza's Sensitivity to OseltamivirJournal of Molecular Biology 2016, 428533–537.

Dewal, M.B.; DiChiara, A.S.; Antonopoulos, A.; Taylor, R.J.; Harmon, C.J.; Haslam, S.M.; Dell, A.; Shoulders, M.D. "XBP1s Links the Unfolded Protein Response to the Molecular Architecture of Mature N-Glycans" Chemistry and Biology 2015, 22, 1301–1312.

Genereux, J.C.; Qu, S.; Zhou, M.; Ryno, L.M.; Wang, S.; Shoulders, M.D.; Kaufman, R.J.; Lasmézasm C.I.; Kelly, J.W.; Wiseman, R.L. "Unfolded Protein Response-Induced ERdj3 Secretion Links Endoplasmic Reticulum Stress to Extracellular ProteostasisEMBO Journal 2015, 34, 419.

Choudhary, A.#; Kamer, K.J.#; Shoulders, M.D.#; Raines, R.T. "4-Ketoproline: An Electrophilic Proline Analog for BioconjugationBiopolymers: Peptide Science 2015, 104, 110115. #Co-First Authors.

Chen, J.J.#; Genereux, J.C.#; Hulleman, J.D.; Shoulders, M.D.; Wiseman, R.L. “ATF6 Activation Reduces the Secretion and Extracellular Aggregation of Destabilized Variants of an Amyloidogenic ProteinChemistry and Biology 2014, 2115641574#Co-First Authors.

Ryno, L.M.; Genereux, J.C.; Naito, T.; Morimoto, R.I.; Powers, E.T.; Shoulders, M.D.; Wiseman, R.L. "Characterizing the Altered Cellular Proteome Induced by the Stress-Independent Activation of Heat Shock Factor I" ACS Chemical Biology 2014, 9, 12731283.

Shoulders, M.D.#; Ryno, L.M.#; Kelly, J.W.; Wiseman, R.L. “Broadly Applicable Methodology for the Dosable, Rapid, and Small Molecule-Mediated Regulation of Transcription Factors in Human Cells” Journal of the American Chemical Society 2013135, 8129–8132. #Co-First Authors.

Shoulders, M.D.; Ryno, L.M.; Genereux, J.C.; Moresco, J.J.; Tu, P.G.; Wu, C.; Yates, J.R. III; Su, A.I.; Kelly, J.W.; Wiseman, R.L. “Stress-Independent Activation of XBP1s and/or ATF6 Reveals Three Functionally Diverse ER Proteostasis Environments” Cell Reports 20133, 1279–1292.

Krow, G.R.; Shoulders, M.D.; Edupuganti, R.; Gandla, D.; Yu, F.; Sonnet, P.E.; Sender, M.; Choudhary, A.; DeBrosse, C.; Ross, C.W.,III; Carroll, P.; Raines, R.T. “Synthesis of 5-Fluoro- and 5-Hydroxymethanoprolines via Lithiation of N-BOC-Methanopyrrolidines. Constrained Cɣ-Exo and Cɣ-Endo Flp and Hyp Conformer Mimics” Journal of Organic Chemistry 201277, 5331–5344. 

Shoulders, M.D.; Raines, R.T. “Interstrand Dipole-Dipole Interactions Can Stabilize the Collagen Triple Helix” Journal of Biological Chemistry 2011286, 22905–22912.

Krow, G.R.; Edupuganti, R.; Gandla, D.; Yu, F.; Sender, M.; Sonnet, P.E.; Zdilla, M.J.; DeBrosse, C.; Cannon, K.C.; Ross, C.W., III; Choudhary, A.; Shoulders, M.D.; Raines, R.T. “Synthesis of Conformationally Constrained 5-Fluoro- and 5-Hydroxymethanopyrrolidines. Ring Puckered Mimics of Gauche and Anti-3-Fluoro- and 3-Hydroxypyrrolidines” Journal of Organic Chemistry 201176, 3626–3634.

Shoulders, M.D.; Kotch F.W.; Choudhary, A.; Guzei, I.A.; Raines, R.T. “The Aberrance of the 4S Diastereomer of 4-Hydroxyproline” Journal of the American Chemical Society, 2010132, 10857–10865.

Shoulders, M.D.; Satyshur, K.A.; Forest, K.T.; Raines, R.T. “Stereoelectronic and Steric Effects in Side Chains Preorganize a Protein Main Chain” Proceedings of the National Academy of Sciences, USA 2010107, 559–564.

Krow, G.R.; Liu, N.; Sender, M.; Lin, G.; Centafont, R.; Sonnet, P.E.; DeBrosse, C.; Ross, C.W., III; Carroll, P.J.; Shoulders, M.D.; Raines, R.T. “Oligomers of a 5-Carboxymethanopyrrolidine β-Amino Acid—A Search for Order” Organic Letters 201012, 5438–5441.

Shoulders, M.D.; Kamer, K.J.; Raines, R.T. “Origin of the Stability Conferred upon Collagen by Fluorination” Bioorganic and Medicinal Chemistry Letters 200919, 3859–3862.

Shoulders, M.D.; Raines, R.T. “Collagen Structure and Stability” Annual Review of Biochemistry 2009,78, 929–958.

Shoulders, M.D.; Raines, R.T. “Modulating Collagen Triple-Helix Stability with 4-Chloro, 4-Fluoro, and 4-Methylprolines” Advances in Experimental Medicine and Biology 2009611, 251–252.

Shoulders, M.D.; Guzei, I.A.; Raines, R.T. “4-Chloroprolines: Synthesis, Conformational Analysis, and Effect on the Collagen Triple Helix” Biopolymers 200889, 443–454.

Shoulders, M.D.; Hodges, J.A.; Raines, R.T. “Reciprocity of Steric and Stereoelectronic Effects in the Collagen Triple Helix” Journal of the American Chemical Society 2006128, 8112–8113.