8/18/17: The Shoulders Lab receives a pilot grant from the NIH-funded MIT Center for Environmental Health Sciences! The funds will support our efforts to understand how zinc deficiency mediates heavy metal toxicity at the mechanistic level, with a focus on cadmium exposure.
7/11/17: The Shoulders Lab is awarded a $1,700,000 R01 grant from the NIH's National Institute of Arthritis and Musculoskeletal and Skin Diseases to support research aimed at defining molecular mechanisms of collagen folding and quality control and discovering potential new therapeutic strategies for osteogenesis imperfecta.
6/13/17: Angela gives a platform presentation on her work on influenza evolution at the Molecular Mechanisms in Evolution Gordon Research Conference.
6/1/17: High school students Ms. Eileen Tan-Aristy and Ms. Rebecca Schooler join the lab for a summer internship. Welcome, Eileen and Rebecca!
5/31/17: Kenny wins a Buchi/Luk Family Graduate Research Fellowship. Congrats, Kenny!
5/25/17: Chris R. is featured in a Chemistry Department "Spotlight"!
5/17/17: Chris R. passes his third-year oral exam and is officially a PhD candidate. Congrats, Chris!
5/3/17: Kenny passes his second-year qualifying exam. Congrats, Kenny!
4/25/17: Chris M. and Duc travel to Chicago, IL to give platform and poster presentations at the National Meeting of the American Society for Biochemistry and Molecular Biology.
3/8/17: Michelle is named a 2017 MIT-Amgen Summer Scholar and will work with us this summer supported by the program. Congrats, Michelle!
3/8/17: Louis passes his 3rd year oral exam and is officially a PhD candidate. Congrats, Louis!
1/5/17: Matt receives the National Science Foundation CAREER Award. The >$1,000,000 grant from NSF's Division of Molecular and Cellular Biosciences that is associated with this award will support our work on protein evolution.
12/20/16: The Shoulders Lab receives funding from the MISTI-Imperial College Seed Fund to support our collaboration on effects of the unfolded protein response on N-glycan maturation with Prof. Anne Dell and Dr. Stuart Haslam at Imperial College in London, UK.
12/7/16: Angela and Anna attend the 2016 Keystone Symposium on Cellular Stress Responses and Infectious Agents in Santa Fe, New Mexico. Angela gives a platform presentation on influenza evolution in altered host proteostasis environments.
12/5/16: Andrew and Madeline spend two weeks in Australia supported by the MIT International Science and Technologies Initiatives working with our collaborators in Prof. John Bateman's and Prof. Shireen Lamande's groups at Murdoch Childrens Research Institute.
12/1/16: Chris Moore featured in the latest issue of Chemformation!
11/22/16: Party in a private room at State Park to welcome all the new group members!
11/18/16: Sam Hendel is the cover model for Volume 93, Issue 8 of J. Chem. Ed. for his paper with Professor Elizabeth Young at Amherst College, "Introduction to Electrochemistry and the Use of Electrochemistry to Synthesize and Evaluate Catalysts for Water Oxidation and Reduction."
11/15/16: Emmanuel attends the H3D Syposium on Malaria, TB, and Neglected Tropical Diseases in Cape Town, South Africa.
11/12/15: Mr. Sam Hendel, Ms. Chichi Li, and Ms. Rebecca Sebastian join the lab as chemistry PhD students. Welcome to the group, Sam, Chichi, and Rebecca!
9/23/16: The Shoulders Lab receives funding from the NIH's National Institute on Aging to support research aimed at elucidating the biophysical consequences of pathologic protein aggregation in living cells.
9/1/16: Michelle Huang, a sophomore in Chemical Engineering, formally joins the lab after spending the summer working on osteogenesis imperfecta with Profs. John Bateman and Shireen Lamande at Murdoch Childrens Research Institute in Melbourne, Australia, supported by our joint MISTI grant. Welcome, Michelle!
6/27/16: The Shoulders Lab receives the Jeptha H. and Emily V. Wade Award for Creative Research. The funds will support our work on the heat shock response. Thanks to the Wade Family for their support!
6/10/16: The Shoulders Lab hosts ~150 local school kids on campus for a "Chemistry Magic Show" in collaboration with MIT's ClubChem. It was a great and highly educational event!
6/6/16: Chris M. presents his development of methods for multi-dimensional, chemogenic control of CRISPR-Cas9 at the Bioorganic Chemistry Gordon Research Conference at Proctor Academy in Andover, NH. Chris won the conference's poster award for his presentation!
6/2/16: Diya Malhotra is back from the University of Michigan for summer research. Welcome back, Diya!
6/1/16: Camden Holm, a local homeschooled high school student, joins the lab for a summer internship. Welcome, Camden!
5/28/16: Matt is named to the Whitehead Career Development Professorship.
5/27/16: Nora Enright, a rising sophomore in Biological Engineering, joins the lab. Welcome, Nora!
5/12/16: Ilana wins the 2016 MIT Department of Chemistry F. D. Greene Teaching Award for outstanding contributions in the area of teaching chemistry. Congrats, Ilana!
5/11/16: Chris M. is awarded a Broadnext10 Research Grant, which funds catalytic steps towards the development of potentially transformative new technologies, by the Broad Institute. The funds will support his work on human cell-based directed evolution. Congrats, Chris!
5/5/16: Louis and Chris R. pass their second year qualifying exams. Congrats to both!
4/20/16: Madeline presents her work on how the unfolded protein response regulates the molecular architecture of the N-glycome at the Cold Spring Harbor Laboratory Protein Homeostasis in Health and Disease Meeting in Cold Spring Harbor, NY. Madeline's trip was supported in part by an MIT Women in Chemistry travel grant sponsored by the MIT CEHS.
4/20/16: Chris M. presents his work on multidimensional, chemogenic regulation of Cas9 at the Cold Spring Harbor Laboratory Protein Homeostasis in Health and Disease Meeting in Cold Spring Harbor, NY.
4/1/16: Duc presents his work on collagen and osteogenesis imperfecta at the 2016 American Society of Biochemistry and Molecular Biology Annual Meeting in San Diego, CA. Duc's trip was supported by a generous travel award from the ASBMB.
4/1/16: Ilana Porter and Dr. Patti Christie join the education side of the Shoulders Group to lead the development of a Fundamental Knowledge Module for Matt's course 5.111 Principles of Chemical Science. Welcome, Ilana and Patti!
3/16/16: Chet, Angela, Madeline, and Chris M. pass their 3rd year oral exams and are officially PhD candidates. Congrats to all!
2/17/16: The d'Arbeloff Fund for Excellence in Education awards a grant to Matt and Prof. Troy Van Voorhis to support the creation of a Foundational Knowledge Module for MITx to accompany their 5.111 Principles of Chemical Science course that hundreds of MIT students participate in each academic year.
12/17/15: The Shoulders Lab receives MISTI Global Seed Funds to support our collaboration on osteogenesis imperfecta with Profs. John Bateman and Shireen Lamande at Murdoch Childrens Research Institute in Melbourne, Australia.
11/12/15: Ms. Anna Ponomarenko and Mr. Kenny Chen join the lab as chemistry PhD students. Welcome to the group, Anna and Kenny!
10/6/15: Matt receives the 2015 National Institutes of Health Director's New Innovator Award. This $2,400,000 grant will fund our efforts to develop new directed evolution platforms for generating active biomolecules for medical and research applications, as well as research into understanding how the proteostasis network influences and directs client protein evolution.
9/5/15: Matt joins the Center for Skeletal Research at Massachusetts General Hospital in Boston, MA as an Investigator. The Center provides exceptional opportunities to rapidly advance our research on the biochemistry of collagen folding by collaborating with bone disease experts and working with animal models.
8/21/15: Chris M., Chet, and Louis spend a week in the Netherlands supported by the MIT International Science and Technologies Initiatives working with our collaborators in Prof. Rob Hoeben's group at Leiden University Medical Center.
8/18/15: Mahender presents his work on the effects of unfolded protein response activation on the molecular architecture of the N-glycome at the 250th National Meeting of the American Chemical Society in Boston, MA.
7/30/15: The Shoulders Lab receives funding from the NIH's National Institute of Arthritis and Musculoskeletal and Skin Diseases to support research aimed at elucidating cellular pathways involved in collagen folding, trafficking, and quality control.
7/1/15: Angela and Emmanuel present their work on influenza and HIV evolution at the Gordon Research Conference on Molecular Mechanisms in Evolution at Stonehill College in Easton, MA. Angela's travel was supported in part by an MIT Women in Chemistry travel grant sponsored by the MIT CEHS.
6/15/15: Caiden Kumar, a local high schooler, joins the lab for summer research. Welcome, Caiden!
6/10/15: Andrew presents his work on collagen-I proteostasis at the Massachusetts General Hospital Center for Skeletal Research Annual Symposium in Boston, MA. Andrew won second place in the poster competition for his work!
6/5/15: Congratulations to our graduating seniors Becca and Patreece! Patreece is continuing on at MIT to wrap up some very nice research findings and then plans to pursue a Ph.D. Becca is traveling across the street to Harvard University for graduate school this fall. Good luck to both!
5/29/15: Angela, Chet, and Madeline pass their second year qualifying exams. Congrats to all!
5/14/15: Louis wins a Buchi/Luk Family Graduate Research Fellowship. Congrats, Louis!
5/14/15: Chet wins an A.D. Masamune Memorial Graduate Research Fellowship. Congrats, Chet!
5/13/15: Chris M. presents his efforts toward the development of a highly potent and selective chemical genetic technique to inhibit Heat Shock Factor 1 at the MIT Center for Environmental Health Sciences Poster Session in Cambridge, MA.
4/25/15: Patreece presents her work developing a new assay for the retrotranslocation of misfolded proteins from the endoplasmic reticulum to the cytosol at the MIT Department of Chemistry Undergraduate Research Symposium in Cambridge, MA.
3/31/15: Chris M. presents his work on modulating cytosolic proteostasis at the 2015 Annual Meeting of the American Society for Biochemistry and Molecular Biology in Boston, MA.
3/30/15: Angela presents her work on influenza evolution at the 2015 Annual Meeting of the American Society for Biochemistry and Molecular Biology in Boston, MA. Angela won the Best Poster Award for her presentation!
3/16/15: The Shoulders Lab joins the MIT Center for Environmental Health Sciences, which is currently supporting our protein folding research via a pilot grant. We look forward to many exciting new scientific opportunities!
3/2/15: Andrew passes his 3rd year oral exam and is officially a PhD candidate. Congrats, Andrew!
2/28/15: Andrew is awarded a National Institutes of Health F31 pre-doctoral fellowship by the National Institute of Arthritis and Musculoskeletal and Skin Diseases for his research on osteogenesis imperfecta. Congrats, Andrew!
1/12/15: Chris M. passes his qualifying exam. Congrats, Chris!
11/13/14: Chris Richardson, a first-year inorganic chemistry PhD student, joins the lab as a joint student with Prof. Steve Lippard. Welcome, Chris!
11/13/14: Louis Papa, a first-year bioorganic chemistry PhD student, joins the lab. Welcome, Louis!
10/13/14: Andrew presents his studies on collagen-I folding and quality control, performed collaboratively with Madeline and Becca, at the 2014 Biennial Meeting of the American Society for Matrix Biology in Cleveland, OH. Andrew won the Outstanding Poster Presentation Award for his work!
10/10/14: The Shoulders Lab receives Phase 2 funding from the Singapore-MIT Alliance for Research and Technology for a collaborative project with Prof. Eng Eong Ooi at Duke-NUS to support our efforts to improve the pharmacological properties of Dengue virus-targeting monoclonal antibodies.
7/16/14: The Shoulders Lab receives a pilot grant from the NIH-funded MIT Center for Environmental Health Sciences! The funds will support our efforts to understand how xenobiotic heavy metals influence protein folding.
6/27/14: Chris Moore wins a Walter L. Hughes Graduate Research Fellowship. Congrats, Chris!
6/26/14: Christopher Hillenbrand joins the lab as a Research Science Institute scholar. Welcome, Christopher!
6/10/14: The Shoulders Lab receives funding from the Royal G. and Mae H. Westaway Family Memorial Fund! The grant will support our work on a novel directed evolution platform.
6/6/14: Congratulations to our graduating senior Chyleigh! Good luck at Georgetown!
6/2/14: Angela wins a Strem Family Graduate Research Fellowship. Congrats, Angela!
6/2/14: Chet wins a Daniel Kemp Graduate Research Fellowship. Congrats, Chet!
6/1/14: Andrew wins an A.D. Masamune Memorial Graduate Research Fellowship. Congrats, Andrew!
5/29/14: Andrew passes his qualifying exam. Congrats, Andrew!
5/20/14: The Shoulders Lab organizes and hosts a workshop on Virus Evolution and Adaptation at MIT. Presenters include the Hoeben, Hartl, Chodosh, Bolon, Sabeti, Runstadler, and Hoekstra groups, with attendees from all around the Cambridge area. Thanks to MISTI for sponsoring the workshop!
5/1/14: The Shoulders Lab receives Phase 1 Pilot Programme Funding from the Singapore-MIT Alliance for Research and Technology to support our efforts to reduce the immunogenicity of recombinant, protein-based therapeutics.
4/30/14: Dr. Ngoc Duc Doan receives a postdoctoral fellowship from the Fonds de Recherche Sante Quebec to support his proposal to identify mechanism-based therapeutic targets for osteogenesis imperfecta. Dr. Doan will join the group in September to begin the project. Congrats, Duc!
3/28/14: Sebasthian Santiago, a freshman in MIT's Chemistry Department, joins the group. Welcome, Sebasthian!
2/7/14: The Shoulders Lab receives an Innovation Grant from the Mizutani Foundation for Glycoscience to support Mahender's studies on stress-induced changes in protein N-glycosylation.
12/31/13: Madeline is awarded a Prof. Amar G. Bose Research Grant. The funds will support her studies on the development of self-healing biomimetic materials. Congrats, Madeline!
12/1/13: Ms. Madeline Wong, Ms. Angela M. Phillips and Mr. Chet Berman join the lab as chemistry PhD students. Welcome to the group, Madeline, Angela and Chet!
11/13/13: Matt receives the Smith Family Foundation Award for Excellence in Biomedical Research. The funds will support our research on influenza adaptation.
11/8/13: Dual group party with the Pentelute lab. Tacos and drinks all around!
9/5/13: Ms. Nancy Lu, a sophomore in MIT's Chemical Engineering program and one of Matt's former 5.111 Principles of Chemistry students, joins the group. Welcome, Nancy!
8/22/13: Andrew wins the MIT Department of Chemistry Award for Outstanding Teaching. Congrats, Andrew!
7/25/13: Chyleigh is awarded research support by the Paul E. Gray Endowed Fund for her summer UROP. Congrats, Chyleigh!
6/14/13: Matt is named the 56th Edward Mallinckrodt Jr. Foundation Faculty Scholar. The funds will support our efforts to develop optical sensors of protein misfolding in live cells and the development of synthetic methods for enzyme-independent tagging of proteins with small molecules in cells.
6/11/13: Ms. Helen Hobbs joins the lab as an MIT-Amgen Summer Scholar. Welcome, Helen!
5/20/13: Andrew wins a C.P. Chu and Y. Lai Graduate Research Fellowship--Congrats, Andrew!
5/20/13: Chris is awarded a Walter L. Hughes Graduate Research Fellowship.
5/16/13: Chyleigh is awarded a 3M UROP fellowship--Congrats, Chyleigh!
3/15/13: Emmanuel's and Khalilah's daughter is born--Congrats!
2/28/13: We expand into 56-545 for additional instrument and bench space!
2/6/13: Chris is named an MITx Fellow for Spring 2013. Congrats, Chris!
12/1/12: Mr. Andrew DiChiara and Mr. Christopher Moore are the first chemistry PhD students to join the group. Welcome, Andrew and Chris!
11/28/12: Matt receives the 2012-2013 Outstanding Recent Alumnus Award from the Virginia Tech College of Science.
9/12/12: Ms. Patreece Suen, a sophomore in MIT's Chemistry Department, joins the group. Welcome, Patreece!
9/12/12: Ms. Chyleigh Harmon, a junior in MIT's Chemistry Department, joins the group. Welcome, Chyleigh!
8/31/12: The Shoulders Lab opens for business. Stop by to meet us and check out our newly renovated space in Building 56-546.
7/23/12: Ms. Abigail Caron, a rising sophomore in MIT's Biology Department, joins the group. Welcome, Abby!
7/16/12: Ms. Rebecca Taylor, a rising sophomore in MIT's Chemistry Department, is the first student to join the nascent Shoulders' "group". Welcome, Becca!